ZFIN Image: Wang et al., 2011, Fig. 4

Image

Figure Caption

Fig. 4 Rock2b function in DFC/KV cells is required for normal asymmetric southpaw expression. (A-C) spaw is normally expressed in left LPM in control embryos (A) at 16- to 18-SS. In contrast, spaw expression was often bilateral in rock2b MO embryos (red arrows in B,C). shh expression (see arrow in A) indicated that embryonic midline structures were intact. (D) The frequency of altered spaw expression (right, bilateral or absent) in control embryos and embryos injected with rock2b MO or DNA encoding DN-Rock proteins. (E-G) spaw expression was altered in DFC^rock2b ^MO embryos (F,G), whereas normal left-sided expression was observed in most control DFC^{control MO} embryos (E). (H) The percentage of DFC^rock2b ^MO and control embryos with spaw defects. n=number of embryos analyzed.

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Acknowledgments

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