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Fig. 7 Expression of col2a1 mRNA by notochord vacuolar cells persists late following lysyl oxidase inhibition. Wild-type embryos were injected with 7.4 ng control morpholino (A), incubated in 10 μM neocuproine (B), incubated in 10 mM β-aminopropionitrile supplemented with 10 μM CuCl2 (C), or injected with 3.7 ng each of loxl1 and loxl5b morpholino (D). In situ hybridization was carried out at 24 hpf, and frozen sections confirmed persistent col2a1 expression following lysyl oxidase inhibition (B–D, arrowhead), as well as floorplate and hypochord staining (A–D, arrows).
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Reprinted from Developmental Biology, 307(2), Gansner, J.M., Mendelsohn, B.A., Hultman, K.A., Johnson, S.L., and Gitlin, J.D., Essential role of lysyl oxidases in notochord development, 202-213, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.