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Fig. 2 The eye field is partially specified but is not maintained in ne2611 mutants. All views, anterior left. (A,B) Expression of otx2, labeling the wild-type retina (A, blue arrow) but not the telencephalon, is absent in the enlarged telencephalon of ne2611 sibling embryos (B). Lateral views; t, optic tectum; telencephalon (arrowhead) delimited by gray dots in B. (C-H) Expression of the earliest eye-field marker rx3 (C-E; dorsal views of flat-mounted embryos), and of rx1 (F-H; lateral views of whole embryos), is initiated normally in ne2611. (I-K) Expression of rx2, normally detected at 3-somites in wild type (K, inset), is never initiated in ne2611 (K). Lateral views of whole embryos.