Gene
rx3
- ID
- ZDB-GENE-990415-238
- Name
- retinal homeobox gene 3
- Symbol
- rx3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have sequence-specific DNA binding activity. Involved in animal organ development and cell fate specification. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in isolated microphthalmia 3. Is expressed in several structures, including forebrain; neural keel; neural plate; presumptive neural plate; and retina. Orthologous to human RAX (retina and anterior neural fold homeobox).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 86 figures from 54 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 22 figures from 12 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| isolated microphthalmia 3 | Alliance | Microphthalmia, syndromic 16 | 611038 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain | Retinal homeobox protein RAX/RAX2 |
|---|---|---|---|---|---|---|
|
UniProtKB:O42358
|
292 |
Interactions and Pathways
No data available
Plasmids
No data available