Gene

rx2

ID
ZDB-GENE-990415-237
Name
retinal homeobox gene 2
Symbol
rx2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have sequence-specific DNA binding activity. Involved in camera-type eye photoreceptor cell differentiation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in isolated microphthalmia 3. Is expressed in eye; immature eye; optic primordium; and presumptive diencephalon. Orthologous to human RAX (retina and anterior neural fold homeobox).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
24 figures from 23 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Nelson et al., 2009
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rx2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
isolated microphthalmia 3 Alliance Microphthalmia, syndromic 16 611038
Associated With rx2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeodomain
Domain IPR003654 OAR domain
Family IPR043562 Retinal homeobox protein RAX/RAX2
Homologous_superfamily IPR009057 Homedomain-like superfamily
Domain Details Per Protein
Protein Length Homedomain-like superfamily Homeobox, conserved site Homeodomain OAR domain Retinal homeobox protein RAX/RAX2
UniProtKB:O42357 327
UniProtKB:F1QNV0 327
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA rx2-201 (1) Ensembl 1,489 nt
mRNA rx2-202 (1) Ensembl 1,138 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations