ZFIN Image: Norton et al., 2005, Fig. 9

Image

Figure Caption

Fig. 9 Both serotonergic raphé neurones and oligodendrocyte precursor cells are severely depleted in mol^-/- embryos. Lateral (A,B,I-N) and dorsal (C-H,O,P) views of brains of wild-type and mol^-/- embryos and wild-type and mol^-/- embryos overexpressing shh (WT + shh; mol + shh) analysed for genes indicated bottom right. (A-D) tphR expression reveals serotonergic neurones. Arrows indicate anterior (AR) and posterior (PR) raphé neurones. Unlabeled arrow in D indicates a few residual tphR + neurons. (E-H) th reveals dopaminergic diencephalic neurones (arrows in E,F); noradrenergic neurones of the LC are labelled both with th and dbh probes. (I-N) olig2 labels oligodendrocyte precursor cells and mbp and plp expression marks nascent oligodendrocytes. Arrows indicate areas of reduced olig2, mbp and plp expression in mol^-/- mutant embryos. (O,P) Arrows indicate increased number of tphR-expressing serotonergic neurones in the wild-type embryo and a rescue of serotonergic neurones in the mol^-/- embryo following shh injection. e, epiphysis; LC, locus coeruleus.

Figure Data

Expression / Labeling details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development