Gene

smad1

ID

ZDB-GENE-991119-8

Name

SMAD family member 1

Symbol

smad1 Nomenclature History

Previous Names

madh1
fb39h09
sb:eu786
SMA- and MAD-related protein 1
wu:fb39h09 (1)
wu:fb97e04

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have DNA binding activity; DNA-binding transcription factor activity; and metal ion binding activity. Involved in several processes, including dorsal/ventral pattern formation; myeloid cell development; and regulation of transcription, DNA-templated. Predicted to localize to cytoplasm; nucleus; and transcription factor complex. Is expressed in several structures, including fin; immature eye; mesoderm; nervous system; and optic primordium. Orthologous to human SMAD1 (SMAD family member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

38 figures from 20 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92101 (19 images)
eu786 (20 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With smad1 Human Ortholog

No data available

Associated With smad1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001132	SMAD domain, Dwarfin-type
Domain	IPR003619	MAD homology 1, Dwarfin-type
Domain	IPR013019	MAD homology, MH1
Family	IPR013790	Dwarfin
Homologous_superfamily	IPR008984	SMAD/FHA domain superfamily
Homologous_superfamily	IPR017855	SMAD-like domain superfamily
Homologous_superfamily	IPR036578	SMAD MH1 domain superfamily

Domain Details Per Protein

Protein	Length	Dwarfin	MAD homology 1, Dwarfin-type	MAD homology, MH1	SMAD domain, Dwarfin-type	SMAD/FHA domain superfamily	SMAD-like domain superfamily	SMAD MH1 domain superfamily
UniProtKB:Q9I8V2 InterPro	472
UniProtKB:Q5PQZ2 InterPro	472

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	smad1-201 (1) Ensembl	Ensembl	3,022 nt	Select Tool ZFIN BLAST
mRNA	smad1-202 (1) Ensembl	Ensembl	3,813 nt	Select Tool ZFIN BLAST
mRNA	smad1-203 (1) Ensembl	Ensembl	3,589 nt	Select Tool ZFIN BLAST
mRNA	smad1-204 (1) Ensembl	Ensembl	3,383 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-smad	polyclonal	smad1 smad5 smad9	IgG	Rabbit	IHC WB	Cell Signaling Technology, Inc.	79
Ab1-smad1	polyclonal	smad1	IgG	Rabbit	WB	Abcam plc	4

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations