Gene

dnmt1

ID

ZDB-GENE-990714-15

Name

DNA (cytosine-5-)-methyltransferase 1

Symbol

dnmt1 Nomenclature History

Previous Names

mta
cb1075 (1)
cb983 (1)
ddn
fb05h01
wu:fb05h01 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have DNA (cytosine-5-)-methyltransferase activity and DNA binding activity. Involved in several processes, including Kupffer's vesicle development; animal organ development; and macromolecule methylation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; and hereditary sensory neuropathy type 1E. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and pectoral fin bud. Orthologous to human DNMT1 (DNA methyltransferase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

36 figures from 18 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb983 (12 images)
cb1075 (16 images)
IMAGE:7140056 (5 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 40 figures from 15 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dnmt1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant cerebellar ataxia, deafness and narcolepsy	Alliance	Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant	604121
hereditary sensory neuropathy type 1E	Alliance	Neuropathy, hereditary sensory, type IE	614116

Associated With dnmt1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR018117	DNA methylase, C-5 cytosine-specific, active site
Conserved_site	IPR031303	DNA methylase, C-5 cytosine-specific, conserved site
Domain	IPR001025	Bromo adjacent homology (BAH) domain
Domain	IPR002857	Zinc finger, CXXC-type
Domain	IPR010506	DMAP1-binding domain
Domain	IPR022702	DNA (cytosine-5)-methyltransferase 1, replication foci domain
Family	IPR001525	C-5 cytosine methyltransferase
Family	IPR017198	DNA (cytosine-5)-methyltransferase 1-like
Family	IPR050390	DNA Cytosine-5 Methyltransferase
Homologous_superfamily	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily
Homologous_superfamily	IPR043151	Bromo adjacent homology (BAH) domain superfamily