Gene

elavl3

ID

ZDB-GENE-980526-76

Name

ELAV like neuron-specific RNA binding protein 3

Symbol

elavl3 Nomenclature History

Previous Names

elavC (1)
elrC (1)
elrc (1)
elav-related C
etID309927.3 (1)
huc
HuC
id:ibd1248
wu:fb77b03
zHuC (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have RNA binding activity. Involved in regulation of neurogenesis. Predicted to localize to ribonucleoprotein complex and viral nucleocapsid. Is expressed in several structures, including nervous system; neural plate; neural tube; neuronal stem cell; and presumptive structure. Orthologous to human ELAVL3 (ELAV like RNA binding protein 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

155 figures from 111 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Coolen et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With elavl3 Human Ortholog

No data available

Associated With elavl3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR003954	RNA recognition motif domain, eukaryote
Domain	IPR034915	HuC, RNA recognition motif 3
Family	IPR002343	Paraneoplastic encephalomyelitis antigen
Family	IPR006548	Splicing factor ELAV/Hu
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	HuC, RNA recognition motif 3	Nucleotide-binding alpha-beta plait domain superfamily	Paraneoplastic encephalomyelitis antigen	RNA-binding domain superfamily	RNA recognition motif domain	RNA recognition motif domain, eukaryote	Splicing factor ELAV/Hu
UniProtKB:A0A8M6YUY6 InterPro	346
UniProtKB:A0A8M2BBS5 InterPro	365
UniProtKB:A0A0R4IC33 InterPro	358
UniProtKB:A0A8M3AYA7 InterPro	366
UniProtKB:A0A8M6YXB4 InterPro	353
UniProtKB:Q6P105 InterPro	359
UniProtKB:P79736 InterPro	345
UniProtKB:A0A8M6Z446 InterPro	352

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	elavl3-201 (1) Ensembl	Ensembl	1,120 nt	Select Tool
mRNA	elavl3-202 (1) Ensembl	Ensembl	3,227 nt	Select Tool
mRNA	elavl3-204 (1) Ensembl	Ensembl	530 nt	Select Tool
mRNA	elavl3-205 (1) Ensembl	Ensembl	4,469 nt	Select Tool ZFIN BLAST
ncRNA	elavl3-003 (1) Ensembl	Ensembl	863 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-elavl	monoclonal	elavl3 elavl4	IgG2b	Mouse	IHC	Santa Cruz Biotechnology, Inc. Life Technologies (Invitrogen) Abcam plc MoBiTec Molecular Biotechnology Molecular Probes, Inc.	478

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations