Gene
tnfrsf1b
- ID
- ZDB-GENE-070410-133
- Name
- tumor necrosis factor receptor superfamily, member 1B
- Symbol
- tnfrsf1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Involved in several processes, including peripheral nervous system axon ensheathment; positive regulation of hematopoietic progenitor cell differentiation; and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including Legionnaires' disease; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Is expressed in several structures, including head; head mesenchyme; hematopoietic system; osteoclast; and scale. Orthologous to human TNFRSF1B (TNF receptor superfamily member 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| psoriasis | nz50Tg + MO2-tnfrsf1b | standard conditions | MartÃnez-Navarro et al., 2020 |
| psoriasis | nc1Tg + MO2-tnfrsf1b | standard conditions | MartÃnez-Navarro et al., 2020 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | TNFR/NGFR cysteine-rich region | Tumor necrosis factor receptor superfamily decoy receptor |
|---|---|---|---|
|
UniProtKB:A0A8M2B2L3
|
426 | ||
|
UniProtKB:F1RAS9
|
425 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnfrsf1b-201
(1)
|
Ensembl | 3,935 nt |
Interactions and Pathways
No data available
Plasmids
No data available