Gene

septin15

ID

ZDB-GENE-061103-265

Name

septin 15

Symbol

septin15 Nomenclature History

Previous Names

sept15
sept7b
fc18f05
fc92f03
wu:fb19h03
wu:fc18f05
wu:fc92f03
zgc:153214 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have GTPase activity and molecular adaptor activity. Involved in several processes, including animal organ development; cardiac muscle contraction; and cilium assembly. Predicted to localize to cell division site and cytoskeleton. Is expressed in several structures, including digestive system; heart; hypoblast; nervous system; and pronephros. Orthologous to human SEPTIN7 (septin 7).

Genome Resources

Note

The original name assignment (sept7b) was based on AA similarity alone. Newer genome information and synteny data suggests that this gene, while orthologous to SEPT7 genes, is not the paralog of sept7a and must there be renamed.

Comparative Information

Expression

All Expression Data

11 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 19 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With septin15 Human Ortholog

No data available

Associated With septin15 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR030379	Septin-type guanine nucleotide-binding (G) domain
Family	IPR008115	Septin 7
Family	IPR016491	Septin
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	P-loop containing nucleoside triphosphate hydrolase	Septin	Septin 7	Septin-type guanine nucleotide-binding (G) domain
UniProtKB:A0A0R4IN26 InterPro	428
UniProtKB:A0A8M9PV25 InterPro	464
UniProtKB:A0A8M2BA90 InterPro	432
UniProtKB:A0JMF4 InterPro	429
UniProtKB:A0A8M9PYI2 InterPro	467
UniProtKB:A0A8M9PMV4 InterPro	468
UniProtKB:A0A8M2BA70 InterPro	433

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	sept15-201 (1) Ensembl	Ensembl	879 nt	Select Tool
mRNA	sept15-202 (1) Ensembl	Ensembl	2,803 nt	Select Tool
mRNA	sept15-203 (1) Ensembl	Ensembl	2,837 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab2-sept7	polyclonal	septin15	IgG	Rabbit	IHC WB	Santa Cruz Biotechnology, Inc.	4

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations