PUBLICATION
Phylogenetic and evolutionary analysis of the septin protein family in metazoan
- Authors
- Cao, L., Ding, X., Yu, W., Yang, X., Shen, S., and Yu, L.
- ID
- ZDB-PUB-071118-13
- Date
- 2007
- Source
- FEBS letters 581(28): 5526-5532 (Journal)
- Registered Authors
- Keywords
- Septin, Phylogenetic analysis, Evolution rate, Tissue expression profile
- MeSH Terms
-
- Animals
- Evolution, Molecular*
- GTP-Binding Proteins/classification*
- GTP-Binding Proteins/genetics*
- Gene Expression Regulation
- Humans
- Organ Specificity
- Phylogeny*
- RNA, Messenger/genetics
- PubMed
- 17967425 Full text @ FEBS Lett.
Citation
Cao, L., Ding, X., Yu, W., Yang, X., Shen, S., and Yu, L. (2007) Phylogenetic and evolutionary analysis of the septin protein family in metazoan. FEBS letters. 581(28):5526-5532.
Abstract
Septins, a conserved family of cytoskeletal GTP-binding proteins, were presented in diverse eukaryotes. Here, a comprehensive phylogenetic and evolutionary analysis for septin proteins in metazoan was carried out. First, we demonstrated that all septin proteins in metazoan could be clustered into four subgroups, and the representative homologue of every subgroup was presented in the non-vertebrate chordate Ciona intestinalis, indicating that the emergence of the four septin subgroups should have occurred prior to divergence of vertebrates and invertebrates, and the expansion of the septin gene number in vertebrates was mainly by the duplication of pre-existing genes rather than by the appearance of new septin subgroup. Second, the direct orthologues of most human septins existed in zebrafish, which suggested that human septin gene repertoire was mainly formed by as far as before the split between fishes and land vertebrates. Third, we found that the evolutionary rate within septin family in mammalian lineage varies significantly, human SEPT1, SEPT 10, SEPT 12, and SEPT 14 displayed a relative elevated evolutionary rate compared with other septin members. Our data will provide new insights for the further function study of this protein family.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping