Gene

pcsk9

ID

ZDB-GENE-060927-1

Name

proprotein convertase subtilisin/kexin type 9

Symbol

pcsk9 Nomenclature History

Previous Names

NARC-1 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have serine-type endopeptidase activity. Involved in central nervous system development and neurogenesis. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in hypobetalipoproteinemia. Is expressed in several structures, including eye; integument; liver; notochord; and pleuroperitoneal region. Orthologous to human PCSK9 (proprotein convertase subtilisin/kexin type 9).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pcsk9 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Hypercholesterolemia, familial, 3	603776
		{Low density lipoprotein cholesterol level QTL 1}	603776

Associated With pcsk9 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR022398	Peptidase S8, subtilisin, His-active site
Domain	IPR000209	Peptidase S8/S53 domain
Domain	IPR010259	Peptidase S8 propeptide/proteinase inhibitor I9
Domain	IPR034193	Proteinase K-like catalytic domain
Domain	IPR041051	Proprotein convertase subtilisin/kexin type 9, C-terminal domain 3
Domain	IPR041254	Proprotein convertase subtilisin/kexin type 9, C-terminal domain 1
Family	IPR015500	Peptidase S8, subtilisin-related
Family	IPR050131	Subtilisin-like serine protease
Homologous_superfamily	IPR036852	Peptidase S8/S53 domain superfamily
Homologous_superfamily	IPR037045	Peptidase S8 propeptide/proteinase inhibitor I9 superfamily

Domain Details Per Protein

Protein	Length	Peptidase S8 propeptide/proteinase inhibitor I9	Peptidase S8 propeptide/proteinase inhibitor I9 superfamily	Peptidase S8/S53 domain	Peptidase S8/S53 domain superfamily	Peptidase S8, subtilisin, His-active site	Peptidase S8, subtilisin-related	Proprotein convertase subtilisin/kexin type 9, C-terminal domain 1	Proprotein convertase subtilisin/kexin type 9, C-terminal domain 3	Proteinase K-like catalytic domain	Subtilisin-like serine protease
UniProtKB:E7F2J6 InterPro	667

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-pcsk9	polyclonal	pcsk9		Rabbit	WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations