Gene
pak2b
- ID
- ZDB-GENE-030131-3759
- Name
- p21 protein (Cdc42/Rac)-activated kinase 2b
- Symbol
- pak2b Nomenclature History
- Previous Names
-
- wu:fc52b03
- zgc:113857
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Involved in blood vessel development. Predicted to localize to cytoplasm. Is expressed in axial vasculature; endoderm; and nervous system. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6898349 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Knobloch syndrome 2 | 618458 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000095 | CRIB domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR033923 | p21 activated kinase binding domain |
| Domain | IPR035064 | p21-activated kinase 2, catalytic domain |
| Family | IPR050285 | STE20 Serine/Threonine-Protein Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036936 | CRIB domain superfamily |
Domain Details Per Protein
| Protein | Length | CRIB domain | CRIB domain superfamily | p21-activated kinase 2, catalytic domain | p21 activated kinase binding domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | STE20 Serine/Threonine-Protein Kinase |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BI44
|
520 | |||||||||
|
UniProtKB:Q4V9B9
|
539 |
Interactions and Pathways
No data available
Plasmids
No data available