Gene

pak2a

ID

ZDB-GENE-021011-2

Name

p21 protein (Cdc42/Rac)-activated kinase 2a

Symbol

pak2a Nomenclature History

Previous Names

pak2 (1)
cb422 (1)
redhead (1)
rhd (1)
si:dz198m22.1
wu:fb71h01
zgc:91798

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Involved in blood vessel development. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Is expressed in several structures, including Kupffer's vesicle; axial mesoderm; axial vasculature; axis; and central nervous system. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:91798 (8 images)
cb422 (22 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pak2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Knobloch syndrome 2	618458

Associated With pak2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000095	CRIB domain
Domain	IPR000719	Protein kinase domain
Domain	IPR033923	p21 activated kinase binding domain
Domain	IPR035064	p21-activated kinase 2, catalytic domain
Family	IPR050285	STE20 Serine/Threonine-Protein Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036936	CRIB domain superfamily

Domain Details Per Protein

Protein	Length	CRIB domain	CRIB domain superfamily	p21-activated kinase 2, catalytic domain	p21 activated kinase binding domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	STE20 Serine/Threonine-Protein Kinase
UniProtKB:Q6DG42 InterPro	517

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pak2a-001 (1)	Havana	2,651 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	pak2a-201 (1) Ensembl	Ensembl	2,681 nt	Select Tool ZFIN BLAST
mRNA	pak2a-202 (1) Ensembl	Ensembl	2,520 nt	Select Tool ZFIN BLAST
mRNA	pak2a-203 (1) Ensembl	Ensembl	2,569 nt	Select Tool
mRNA	pak2a-204 (1) Ensembl	Ensembl	1,564 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-pak		pak1 pak2a pak2b		Rabbit	IHC		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations