Gene
apol1
- ID
- ZDB-GENE-030131-3217
- Name
- apolipoprotein L, 1
- Symbol
- apol1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable lipid binding activity. Acts upstream of or within glomerular filtration; podocyte development; and pronephric glomerulus morphogenesis. Predicted to be located in extracellular region and membrane. Is expressed in brain; heart; integument; liver; and pleuroperitoneal region. Used to study kidney disease. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and schizophrenia. Orthologous to several human genes including APOL1 (apolipoprotein L1) and APOL4 (apolipoprotein L4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Glomerulosclerosis, focal segmental, 4, susceptibility to} | 612551 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| kidney disease | AB/EKW + MO2-apol1 | standard conditions | Anderson et al., 2015 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR008405 | Apolipoprotein L |
Domain Details Per Protein
| Protein | Length | Apolipoprotein L |
|---|---|---|
|
UniProtKB:A0A8M2BIK6
|
440 | |
|
UniProtKB:A0A8M2BIK2
|
464 | |
|
UniProtKB:A0A8M2BJ26
|
465 | |
|
UniProtKB:Q7T131
|
326 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available