Gene
impdh2
- ID
- ZDB-GENE-030114-5
- Name
- IMP (inosine 5'-monophosphate) dehydrogenase 2
- Symbol
- impdh2 Nomenclature History
- Previous Names
-
- cb635 (1)
- wu:fb64g02
- wu:fc43f09
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have IMP dehydrogenase activity; metal ion binding activity; and nucleotide binding activity. Involved in circadian rhythm. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including digestive system; immature eye; mesoderm; muscle; and nervous system. Orthologous to human IMPDH2 (inosine monophosphate dehydrogenase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb635 (18 images)
- IMAGE:7166281 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Li et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [IMPDH2 enzyme activity, variation in] | 617995 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR015875 | IMP dehydrogenase / GMP reductase, conserved site |
| Domain | IPR000644 | CBS domain |
| Domain | IPR001093 | IMP dehydrogenase/GMP reductase |
| Family | IPR005990 | Inosine-5'-monophosphate dehydrogenase |
| Homologous_superfamily | IPR013785 | Aldolase-type TIM barrel |
| Homologous_superfamily | IPR046342 | CBS domain superfamily |
Domain Details Per Protein
| Protein | Length | Aldolase-type TIM barrel | CBS domain | CBS domain superfamily | IMP dehydrogenase/GMP reductase | IMP dehydrogenase / GMP reductase, conserved site | Inosine-5'-monophosphate dehydrogenase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:B0UXP9
|
514 | ||||||
|
UniProtKB:Q7ZYW9
|
514 | ||||||
|
UniProtKB:A0A8M2BEA6
|
534 | ||||||
|
UniProtKB:A0A8M9Q3A2
|
558 | ||||||
|
UniProtKB:A0A8M9Q9I4
|
538 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
impdh2-201
(1)
|
Ensembl | 2,335 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-impdh2 | polyclonal | IgG | Rabbit |
|
Proteintech
|
1 |
Plasmids
No data available