Gene
mcm5
- ID
- ZDB-GENE-021209-1
- Name
- minichromosome maintenance complex component 5
- Symbol
- mcm5 Nomenclature History
- Previous Names
-
- MCM5 minichromosome maintenance deficient 5
- wu:fb34a06 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to contribute to 3'-5' DNA helicase activity and single-stranded DNA helicase activity. Involved in chordate embryonic development; mitotic cell cycle; and negative regulation of apoptotic process. Predicted to localize to MCM complex and nucleus. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 8. Is expressed in several structures, including endoderm; head; nervous system; pronephric duct; and tail bud. Orthologous to human MCM5 (minichromosome maintenance complex component 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55720 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Meier-Gorlin syndrome 8 | Alliance | ?Meier-Gorlin syndrome 8 | 617564 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018525 | Mini-chromosome maintenance, conserved site |
| Domain | IPR001208 | MCM domain |
| Domain | IPR027925 | MCM, N-terminal domain |
| Domain | IPR033762 | MCM OB domain |
| Domain | IPR041562 | MCM, AAA-lid domain |
| Domain | IPR054125 | MCM5, C-terminal domain |
| Family | IPR008048 | DNA replication licensing factor Mcm5 |
| Family | IPR031327 | Mini-chromosome maintenance protein |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | DNA replication licensing factor Mcm5 | MCM5, C-terminal domain | MCM, AAA-lid domain | MCM domain | MCM, N-terminal domain | MCM OB domain | Mini-chromosome maintenance, conserved site | Mini-chromosome maintenance protein | Nucleic acid-binding, OB-fold | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NV07
|
736 |
Interactions and Pathways
No data available
Plasmids
No data available