FIGURE

Figure 3.

ID

ZDB-FIG-241114-11

Publication

Garg et al., 2024 - Axon demyelination and degeneration in a zebrafish spastizin model of hereditary spastic paraplegia

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Figure 3.

Lack of Spastizin affects the function of M-cells. (a) shows the tortuosity of the zebrafish over time as median with the surrounding 95% confidence interval. Tortuosity is defined as the difference in the body length and the distance between the head and tail of the animal, normalized to the body length. A value of 0 signifies the animal is entirely straight and 1 tortuosity signifies that head and tail touch. (b) presents the absolute velocity during the same time window. (c) shows the instantaneous spike frequency over time, as in (a) The dashed vertical line marks the time of the stimulus presentation. (d) shows the mean histogram of the occurrence of large spikes during the same time window. All three parameters are low for homozygous mutants compared to heterozygous and wild-types (no. of fish: wt = 9, +/− = 18, −/− = 5). Statistical significance was tested with Fisher’s permutation test (*p < 0.05) and showed a significant reduction in large spikes in mutants compared to wild-type animals.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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