FIGURE

Fig. 4

ID

ZDB-FIG-240703-21

Publication

Won et al., 2020 - Fibulin 5, a human Wharton's jelly-derived mesenchymal stem cells-secreted paracrine factor, attenuates peripheral nervous system myelination defects through the Integrin-RAC1 signaling axis

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Fig. 4

FBLN5 regulates Integrin-mediated actin dynamics in Schwann cells. A, Images of mouse primary Schwann cells double immunostained with Sox10 and F-actin antibodies after treatment with recombinant FBLN5 alone or with an integrin inhibitor (Integrin Ihb). PBS-treated Schwann cells were used as controls. Arrowheads and arrows indicate lamellipodia and filopodia, respectively. Scale bars, 20 μm. B-D, Quantification of axial cell length in (B), lamellipodia number/cell in (C), and lamellipodia length/cell in (D) from data examined using the ImageJ software within equivalent fields of view in the images of (A). The data are shown as the mean ± SD of three independent experiments. Statistical significance was determined using one-way ANOVA followed by Tukey's post hoc test (*P < .05, **P < .005; ns, nonsignificant)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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