FIGURE

Fig. 4

ID

ZDB-FIG-240702-85

Publication

Li et al., 2023 - Establishment of a non-alcoholic fatty liver disease model by high fat diet in adult zebrafish

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Fig. 4

RNA-seq analysis of changes in gene transcript levels during NALFD progression. (A) GSEA analysis of differentially expressed genes with significant upregulation of response pathways to endoplasmic reticulum stress. (B) Bubble plot of GO analysis restlt, lipid synthesis, insulin response and endoplasmic reticulum stress pathways were significantly upregulated. (C) Screening results of cytoHubba app module with the top 20 highest scoring genes. (D) qRT-PCR validation of mRNA expression levels of endoplasmic reticulum stress molecules, fatty acid synthase and insulin substrate receptor (more than three samples were tested for each gene). n.s., no statistical significance, *p < 0.05, **p < 0.01, ***p < 0.001.

Expression Data

Genes:	dnajc3a fasn hspa5 irs2a
Fish:	AB
Condition:	high fat
Anatomical Term:	liver
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Condition:	high fat
Observed In:	liver
Stage:	Adult

Phenotype Detail

Acknowledgments

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