Gene
fasn
- ID
- ZDB-GENE-030131-7802
- Name
- fatty acid synthase
- Symbol
- fasn Nomenclature History
- Previous Names
-
- FAS (1)
- fj34h12
- wu:fj34h12
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have several functions, including fatty acid synthase activity; hydrolase activity, acting on ester bonds; and phosphopantetheine binding activity. Involved in response to (R)-carnitine. Is expressed in liver and male organism. Orthologous to human FASN (fatty acid synthase).
- Genome Resources
- Note
-
Transcripts from ENSDARG00000087657 in Ensembl GRCz11 are associated with ccdc57 and fasn. fasn-202 (ENSDART00000124982) should be associated with ccdc57. Other transcripts belong with fasn. Alternate gene (haplotype) in GRCz11 is ENSDARG00000113553.
- Comparative Information
-
- All Expression Data
- 65 figures from 57 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018201 | Beta-ketoacyl synthase, active site |
| Domain | IPR001031 | Thioesterase |
| Domain | IPR009081 | Phosphopantetheine binding ACP domain |
| Domain | IPR013968 | Polyketide synthase, ketoreductase domain |
| Domain | IPR014030 | Beta-ketoacyl synthase-like, N-terminal |
| Domain | IPR014031 | Beta-ketoacyl synthase, C-terminal |
| Domain | IPR014043 | Acyl transferase domain |
| Domain | IPR020806 | Polyketide synthase, phosphopantetheine-binding domain |
| Domain | IPR020807 | Polyketide synthase, dehydratase domain |
| Domain | IPR020841 | Polyketide synthase, beta-ketoacyl synthase domain |
| Domain | IPR020843 | Polyketide synthase, enoylreductase domain |
| Domain | IPR032821 | Polyketide synthase, C-terminal extension |
| Domain | IPR049391 | Fatty acid synthase, pseudo-KR domain |
| Domain | IPR049552 | Polyketide synthase, dehydratase domain, N-terminal |
| Domain | IPR049900 | Polyketide/metazoan fatty acid synthase, dehydratase domain |
| Family | IPR050091 | Polyketide and Nonribosomal Peptide Biosynthesis Enzymes |
| Homologous_superfamily | IPR001227 | Acyl transferase domain superfamily |
| Homologous_superfamily | IPR011032 | GroES-like superfamily |
| Homologous_superfamily | IPR016035 | Acyl transferase/acyl hydrolase/lysophospholipase |
| Homologous_superfamily | IPR016036 | Malonyl-CoA ACP transacylase, ACP-binding |
| Homologous_superfamily | IPR016039 | Thiolase-like |
| Homologous_superfamily | IPR029058 | Alpha/Beta hydrolase fold |
| Homologous_superfamily | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
| Homologous_superfamily | IPR036736 | ACP-like superfamily |
| Homologous_superfamily | IPR042104 | Polyketide synthase, dehydratase domain superfamily |
| PTM | IPR006162 | Phosphopantetheine attachment site |
Domain Details Per Protein
| Protein | Length | ACP-like superfamily | Acyl transferase/acyl hydrolase/lysophospholipase | Acyl transferase domain | Acyl transferase domain superfamily | Alpha/Beta hydrolase fold | Beta-ketoacyl synthase, active site | Beta-ketoacyl synthase, C-terminal | Beta-ketoacyl synthase-like, N-terminal | Fatty acid synthase, pseudo-KR domain | GroES-like superfamily | Malonyl-CoA ACP transacylase, ACP-binding | NAD(P)-binding domain superfamily | Phosphopantetheine attachment site | Phosphopantetheine binding ACP domain | Polyketide and Nonribosomal Peptide Biosynthesis Enzymes | Polyketide/metazoan fatty acid synthase, dehydratase domain | Polyketide synthase, beta-ketoacyl synthase domain | Polyketide synthase, C-terminal extension | Polyketide synthase, dehydratase domain | Polyketide synthase, dehydratase domain, N-terminal | Polyketide synthase, dehydratase domain superfamily | Polyketide synthase, enoylreductase domain | Polyketide synthase, ketoreductase domain | Polyketide synthase, phosphopantetheine-binding domain | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Thioesterase | Thiolase-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7F5V3
|
2514 | |||||||||||||||||||||||||||
|
UniProtKB:F8W3U6
|
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UniProtKB:A0A8M9Q0T1
|
724 |
Interactions and Pathways
No data available
Plasmids
No data available