FIGURE

Figure 3

ID

ZDB-FIG-240620-263

Publication

Xia et al., 2024 - Inhibition of PIKfyve Leads to Lysosomal Disorders via Dysregulation of mTOR Signaling

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Figure 3

The defects in PIKfyve mutants are dependent on sustained mTOR activation. (A) mTOR inhibitor (Rapa or Torin-1) treatment or effective mTOR knockout (mTOR_KO) attenuates the developmental defects in PIKfyve mutants. Scale bar, 20 µm. (B) Survival curve showing that the lifespan of MU embryos can be extended when mTOR is inhibited by chemical (Rapa, Torin-1) or genetic (mTOR_KO) approaches (N = 3, n = 30 per group). (** p < 0.01, log-rank test). (C) Quantification of diameter of macrophages in MU zebrafish embryos treated as in (A) (**** p < 0.0001, one-way ANOVA).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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