FIGURE

Figure 2

ID

ZDB-FIG-240620-262

Publication

Xia et al., 2024 - Inhibition of PIKfyve Leads to Lysosomal Disorders via Dysregulation of mTOR Signaling

Other Figures

All Figure Page

Back to All Figure Page

Figure 2

PIKfyve deficiency leads to the accumulation of enlarged LAMP1-positive compartments in macrophages. (A–D) The giant vacuoles in mutant macrophages were revealed to be fused lysosomes by staining with LysoTracker (A) or anti-LAMP1 antibody (C). (B) and (D) respectively show the quantification of LysoTracker and LAMP1 fluorescence intensity (** p < 0.01, **** p < 0.0001). Scale bar, 20 µm. (E) Representative confocal images and tracks of macrophage movement in the CHT of WT and MU zebrafish larvae at 3 dpf. Tracks are coded for speed. Scale bar, 50 µm. (F) Quantification of migration speed of macrophages in (E) (** p < 0.01).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cells