FIGURE

Fig. 2

ID

ZDB-FIG-240603-83

Publication

Breuer et al., 2024 - CHD7 regulates craniofacial cartilage development via controlling HTR2B expression

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Fig. 2

Precaudal vertebrae and Weberian apparatus. (A) Representative microCT overview image of the spinal column from a 1-year old chd7+/+ and a chd7-/- adult zebrafish. (B) MicroCT Image of the Weberian apparatus from a 1-year old chd7+/+ and a chd7-/- mutants, indicating structures of intercalarium (red), tripus (yellow) and parapophysis (blue). (C) Sketch diagram of precaudal vertebrae (frontal and lateral) indicating structure and measured angles. (D, E) (top) Individual rendering of precaudal vertebrae, frontal view of tissue over 0.41 g HA/cm3 threshold and (bottom) vBMD intensity map (Range blue-red; 0.41 – 1.00 g HA/cm3) showing morphological abnormalities and growth zone malformations with highly mineralized inclusions (arrow). (F) Neural arch angle. (G) vBMD of whole vertebrae showing increasing density. (H) Increasing ratio of vBMD arch/vertebrae body. (I-K) BV, TV and ratio BV/TV (n = 8/genotype were analyzed). * denotes P < 0.05 and ns = not significant; Student’s t-test

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	chd7^iaf17/iaf17
Observed In:	centrum intercalarium neural arch parapophysis precaudal vertebra precaudal vertebra bone mineralization supraneural tripus vertebra Weberian apparatus
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Bone Miner. Res.