FIGURE

Fig. 2

ID

ZDB-FIG-240222-135

Publication

Yang et al., 2023 - nkx2.3 is responsible for posterior pharyngeal cartilage formation by inhibiting Fgf signaling

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Fig. 2

Malformation of pharyngeal cartilages in nkx2.3 mutants. (A) Knockout of nkx2.3 by CRISPR-Cas9 system. The nkx2.3△76 allele was identified by the targeting of the second exon of the nkx2.3 locus (top panel), which carried a 76-bp deletion resulting in a premature stop codon. The truncated protein in nkx2.3△76 mutants only has 130 amino acids (bottom panel). (B) Morphology of nkx2.3 mutant embryos at indicated stages. Scale bars, 200 μm. (C) Photomicrographs of the cartilages stained with Alcian blue. The cartilages were shown anterior to the left and included the ceratobranchial (cb), ceratohyal (ch), Meckel's cartilage (m), and palatoquadrate (pq) cartilages. Scale bars, 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nkx2.3^bj2/bj2 (TU)
Observed In:	ceratobranchial cartilage mandibular arch skeleton pericardium whole organism
Stage Range:	Long-pec to Day 4

Phenotype Detail

Acknowledgments

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