FIGURE

Figure 7

ID

ZDB-FIG-240113-36

Publication

Sobah et al., 2023 - Contribution of Signal Transducer and Activator of Transcription 3 (STAT3) to Bone Development and Repair

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Figure 7

Effect of Stat3 mutations on innate immune response to amputation. Representative caudal fin of wildtype (WT: A,E), knockout (KO: B,F), and transactivation domain truncation (ΔTAD: C,G) zebrafish larvae on either the Tg(mpeg1.1:GFP) (A–C) or Tg(mpx:GFP) (E–G) backgrounds stained with Alizarin red (Alizarin) at the timepoints indicated, showing GFP fluoresce and Alizarin staining separately and then overlaid (Merge), with scale bars representing 1 mm. Quantitation of mpeg1.1+ cells (D) and mpx+ cells (H) at the indicated times postamputation with mean and SEM, showing statistical significance between WT and KO (*** p < 0.001) as well as WT and ΔTAD (### p < 0.001, ## p < 0.01).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	stat3^mdu35/mdu35; gl22Tg stat3^mdu35/mdu35; i114Tg stat3^mdu36/mdu36; gl22Tg stat3^mdu36/mdu36; i114Tg
Observed In:	caudal fin macrophage caudal fin neutrophil innate immune response
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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