FIGURE

Fig. 6.

ID

ZDB-FIG-231212-63

Publication

Karoglu-Eravsar et al., 2023 - Long-term Acetylcholinesterase Depletion Alters the Levels of Key Synaptic Proteins while Maintaining Neuronal Markers in the Aging Zebrafish (Danio rerio) Brain

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6.

Summary figure indicating alterations in response to long-term reduction of AChE activity and aging. Overall, brain levels of AChE activity and ACh content decrease significantly in the ache mutants. On the other hand, mutants as compared to wildtype controls are characterized by elevated levels of the immature neuronal marker, HuC, and reduced levels of the glial marker, GFAP, as well as excitatory synaptic proteins GluR2/3 and NR2B. In wildtype animals, the cholinergic ratio AChE/ACh declines with increasing age, while this index is stable in the mutants across the lifespan. Additionally, with aging, the levels of presynaptic protein SYP are elevated in the ache zebrafish. The figure was created with BioRender.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Gerontology