FIGURE

Fig. 1.

ID

ZDB-FIG-231212-58

Publication

Karoglu-Eravsar et al., 2023 - Long-term Acetylcholinesterase Depletion Alters the Levels of Key Synaptic Proteins while Maintaining Neuronal Markers in the Aging Zebrafish (Danio rerio) Brain

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Fig. 1.

A comparison in the brain levels of cholinergic transmission components between genotype and age groups. a AChE enzymatic activity was significantly reduced in both young (10–11 months old) and old (30–31 months old) ache mutants as compared to wildtype animals, and a significant overall age-related decline in AChE activity was observed. b A significant effect of genotype was revealed in brain ACh levels with ache mutants having reduced levels of ACh. c An age-dependent decline that was more robust in the wildtype group was revealed in the AChE/ACh ratio. d No significant change was observed in the protein expression levels of the cholinergic receptor subunit nAChR-a7. The group means + standard error (SE) are represented. *: p <0.05, ***: p <0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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