FIGURE

Figure 5

ID

ZDB-FIG-231002-368

Publication

Sarkar et al., 2023 - Oxidative and Endoplasmic Reticulum Stress Represent Novel Therapeutic Targets for Choroideremia

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Figure 5

Analysis of oxidative stress in NACA-treated chm^ru848 fish and CHM^Y42X cells. Fish were treated with 200 µg/mL of NACA at 10 hpf and collected at 5 dpf for (A) retinal histology and (B) RT-qPCR analysis of the oxidative stress markers txn, cat and sod3a. (C) Cells were treated with either 1 mM of NACA, and the expression of SOD2 and the ER stress markers CHOP and BIP was analysed using RT-qPCR. Data are expressed as mean ± SEM from n = 3. * p ≤ 0.05, ** p ≤ 0.01, *** < p ≤ 0.001. Scale bar (50 μm), shown in wt corresponds to all images in panel.

Expression Data

Genes:	cat sod3a txnb
Fish:	AB chm^ru848/ru848 (AB)
Condition:	chemical treatment by environment: N-Acetylcysteine amide
Anatomical Term:	whole organism
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	chm^ru848/ru848 (AB)
Condition:	chemical treatment by environment: N-Acetylcysteine amide
Observed In:	lens retina retinal pigmented epithelium whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Antioxidants (Basel)