FIGURE

Figure 4

ID

ZDB-FIG-231002-367

Publication

Sarkar et al., 2023 - Oxidative and Endoplasmic Reticulum Stress Represent Novel Therapeutic Targets for Choroideremia

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Figure 4

Analysis of ER stress in taurine-treated chm^ru848 fish and CHM^Y42X cells. Fish were treated with 100 mM of taurine at 3 dpf and collected at 5 dpf for (A) retinal histology and RT-qPCR analysis of (B) the ER stress markers atf6, bip and atf4 and (C) the oxidative stress markers txn, cat and sod3a. (D) Cells were treated with 100 mM of taurine and the expression of SOD2 and ER stress markers CHOP and BIP was analysed using RT-qPCR. Data are expressed as mean ± SEM from n = 3. * p ≤ 0.05, *** < p ≤ 0.001. Scale bar (50 μm), shown in wt corresponds to all images in panel.

Expression Data

Genes:	atf4a atf6 cat hspa5 sod3a txnb
Fish:	AB chm^ru848/ru848 (AB)
Condition:	chemical treatment by environment: taurine
Anatomical Term:	whole organism
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	chm^ru848/ru848 (AB)
Condition:	chemical treatment by environment: taurine
Observed In:	lens retina retinal pigmented epithelium whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Antioxidants (Basel)