FIGURE

Figure 4

ID

ZDB-FIG-230916-134

Publication

Shi et al., 2023 - Deletion of the chd7 Hinders Oligodendrocyte Progenitor Cell Development and Myelination in Zebrafish

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Figure 4

Chd7 knockout suppressed OPC migration. (a) Representative image of dorsally migrated olig2⁺ cells at 3, 4, 5, and 6 dpf between chd7^+/+ and chd7^−/− groups. Scale bar: 100 μm. (b) The number of dorsally migrated olig2⁺ cells at 3, 4, 5, and 6 dpf decreased in chd7^−/− group. Data shown as mean ± sem. 3 dpf, ** p = 0.0023; 4 dpf, **** p < 0.0001; 5 dpf, **** p < 0.0001; 6 dpf, p = 0.7349, ns: not significant, unpaired Student’s two-tailed t-test. (c) Representative image of total and dorsally migrated olig2⁺ cells at 4 dpf between chd7^+/+ and chd7^−/− group. Scale bar: 10 μm. (d) The number of total olig2⁺ cells at 4 dpf did not differ significantly between the two groups, ns: not significant. The number of dorsally migrated olig2⁺ cells at 4 dpf decreased in chd7^−/− group. ** p = 0.0075, unpaired Student’s two-tailed t-test.

Expression Data

Gene:	EGFP
Fish:	vu12Tg (AB) chd7^ah517/ah517; vu12Tg (AB)
Anatomical Term:	spinal cord oligodendrocyte
Stage Range:	Protruding-mouth to Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	chd7^ah517/ah517; vu12Tg (AB)
Observed In:	spinal cord oligodendrocyte
Stage Range:	Protruding-mouth to Day 6

Phenotype Detail

Acknowledgments

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