FIGURE

Figure 7

ID

ZDB-FIG-230814-148

Publication

Giardoglou et al., 2023 - Cfdp1 Is Essential for Cardiac Development and Function

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Figure 7

cfdp1 abrogation does not affect Notch signaling. (A) Notch signaling remains unaffected in cfdp1 morphants compared to the uninjected sibling controls. Max projection of z-stack confocal images of 72 hpf cfdp1-MO embryos. Ventricular cardiomyocytes are labeled with green (Tg(myl7:GFP)) and Notch-activated cells are labeled with red (Tg(Tp1:mCherry)). n = 10 in each of three independent experiments. Scale bar 150 μm. (B) Confocal images of 120 hpf cfdp1 mutant and wild-type siblings expressing Tg(TP1:mcherry) in Notch-activated cells and Tg(cmlc2:eGFP) in all cardiomyocytes. (N = 3, n = 12) A: atrium; V: ventricle; B: bulbus arteriosus; scale bar: 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cfdp1^aa106/aa106; s939Tg; twu34Tg s939Tg; twu34Tg + MO2-cfdp1
Knockdown Reagent:	MO2-cfdp1
Observed In:	heart Notch signaling pathway
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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