FIGURE

FIGURE 4

ID

ZDB-FIG-230601-24

Publication

Bai et al., 2023 - Association analysis and functional follow-up identified common variants of JAG1 accounting for risk to biliary atresia

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FIGURE 4

Knockdown of jag1a or jag1b led to biliary dysfunction in zebrafish. (A) The right lying view of 5dpf zebrafish larvae after swallowing PED-6 showed that the gallbladders of jag1a or jag1b morphants were weaker and smaller than those of embryos injected with control MO. (B) Quantitative analysis showed that the accumulation of PED-6 in the gallbladders of jag1a or jag1b morphants were significantly reduced (p < 0.0001, χ² test). Scale bar = 100 μm *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Abbreviations: dpf, day post fertilization; PED-6, N-((6-(2,4-dinitrophenyl) amino) hexanoyl)-1-palmitoyl-2-BODIPY-FL-pentanoyl-sn-glycero-3-phosphoethanolamine.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO3-jag1b AB + MO6-jag1a AB + MO7-jag1a AB + MO9-jag1b
Knockdown Reagents:	MO3-jag1b MO6-jag1a MO7-jag1a MO9-jag1b
Observed In:	gall bladder liver and biliary system
Stage:	Day 5

Phenotype Detail

Acknowledgments

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