FIGURE

Figure 6

ID

ZDB-FIG-230601-12

Publication

Azad et al., 2023 - Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B

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Figure 6

CSNK2B plays a critical role in regulating erythropoiesis in vivo.

(A) Csnk2b is required for hemoglobinization of zebrafish erythrocytes. Representative images of hemoglobin signal in control and csnk2b morphants stained with o-dianisidine at 2 dpf. Images shown are ventral views with heads to the top. (B) Statistical analyses showing dose-dependent loss of hemoglobin in embryos injected with 1, 3, or 5 ng of control (CTL) or csnk2b morpholino. (C) Statistical analysis of hemoglobin phenotypes in control and csnk2b morphants with or without rescue of csnk2b mRNA. Representative images of hemoglobin classification criterion are shown on the right side of the graph. Data collected from 3 independent experiments, with corresponding embryo numbers displayed on the columns. ****P < 0.0001. For B and C, χ² tests were performed to examine the statistical difference of the phenotype distribution between groups.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-csnk2b
Knockdown Reagent:	MO1-csnk2b
Observed In:	erythrocyte differentiation nucleate erythrocyte hemoglobin
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Journal of Clin. Invest.