FIGURE

Figure 5

ID

ZDB-FIG-230523-48

Publication

Silva et al., 2023 - In a zebrafish biomedical model of human Allan-Herndon-Dudley syndrome impaired MTH signaling leads to decreased neural cell diversity

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Figure 5

MTH is directly involved in the development of discrete her2, dla, and fabp7a cells. Colocalization of zebrafish thraa, thrab, and mct8 with her2 and dla expressing cells at after double WISH. thraa, thrab and mct8 (green); her2, dla and fabp7a (red) and colocalization (yellow). (A) At 25hpf, thraa/her2 colocalization in CTRLMO embryos (arrow) is increased in the apical spinal cord, while in MCT8MO thraa/her2 colocalization has a more medial distribution in the spinal cord (arrowhead). (B) At 25hpf, thrab/dla colocalization is less predominant in MCT8MO embryos, and asterisks denote decreased colocalization along the anterior-posterior axis of the spinal cord. Arrowheads indicate the increased colocalization of thrab/dla+ in cells of the ventral spinal cord in MCT8MO embryos. (C) At 48hpf, mct8/fabp7a colocalization in CTRLMO occurs scattered through the spinal cord with an arrow indicating colocalization in the dorsal spinal cord and arrowhead colocalization in the ventral spinal cord. Colocalization of fabp7a with thraa and thrab in MCT8MO embryos is more restricted to the ventrally located fabp7a+ cells (blue arrowheads). All images depict a spinal cord section between somite 8-12; rostral is left and dorsal up. White dashed lines show the boundary of the spinal cord. A minimum of 3 individuals/conditions was analyzed. The scale bar represents 20µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Endocrinol (Lausanne)