FIGURE

Fig. 3.

ID

ZDB-FIG-230518-104

Publication

Keatinge et al., 2023 - Unexpected phenotypic and molecular changes of combined glucocerebrosidase and acid sphingomyelinase deficiency

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Fig. 3.

Accumulation of key glycolipids across gba1^−/− and smpd1^−/− single-mutant and gba1^−/−;smpd1^−/− double-mutant genotypes. Relative glucosylceramide (A), lactosylceramide (B), ceramide (C), sphinganine (D), sphingosine (E) and sphingomyelin (F) levels in WT, single-mutant gba1^−/− and smpd1^−/−, and double-mutant gba1^−/−;smpd1^−/− zebrafish. n=10 brains from 12-week-old zebrafish used per group. Data represented are the mean±s.d. *P<0.05; **P<0.01; ****P<0.0001 (two-way ANOVA with Tukey's multiple comparisons).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gba1^sh391/sh391 smpd1^sh696/sh696 gba1^sh391/sh391; smpd1^sh696/sh696
Observed In:	brain beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide brain ceramide brain glucosylceramide brain sphinganine brain sphingomyelin brain sphingosine
Stage:	Adult

Phenotype Detail

Acknowledgments

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