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Fig. 3.
Accumulation of key glycolipids across gba1−/− and smpd1−/− single-mutant and gba1−/−;smpd1−/− double-mutant genotypes. Relative glucosylceramide (A), lactosylceramide (B), ceramide (C), sphinganine (D), sphingosine (E) and sphingomyelin (F) levels in WT, single-mutant gba1−/− and smpd1−/−, and double-mutant gba1−/−;smpd1−/− zebrafish. n=10 brains from 12-week-old zebrafish used per group. Data represented are the mean±s.d. *P<0.05; **P<0.01; ****P<0.0001 (two-way ANOVA with Tukey's multiple comparisons).
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