FIGURE

Fig. 4

ID

ZDB-FIG-230317-7

Publication

Smith et al., 2021 - Lysosomes and the pathogenesis of merosin-deficient congenital muscular dystrophy

Other Figures

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Fig. 4

Lysosome distribution in sap mutants. (A) Lamp1-RFP expression in WT embryos shows that lysosomes are distributed throughout the cytoplasm in myofibers but not at myosepta (white arrows) at 4 dpf. (B–C) There is no significant redistribution of lysosomes to the myosepta (white arrows) in sap mutants at 4 dpf (n = 14 fibers), in either attached nor detached fibers. Yellow arrows indicate where fibers have detached from the myosepta. (D) Lamp1-RFP fluorescence intensity at the myosepta was not significantly different in sap mutants at 4 dpf (P = 0.6814, n = 14 fibers) compared with WT. Bars represent mean ± SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dmd^{ta222a/ta222a}
Observed In:	lysosome localization
Stage:	Day 4

Phenotype Detail

Acknowledgments

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