FIGURE
Fig 1
- ID
- ZDB-FIG-230315-51
- Publication
- Xie et al., 2023 - Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish
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Fig 1
Mutation of ccdc57 leads to scoliosis.
(A) Representative images of male and female wild type and tft168N mutants. (B) Micro-CT images showing lateral and dorsal views of 3-months-old wild type and tft168N mutants. (C) Genomic structure and sequences of wild type, tft168N mutant and two ccdc57 mutant alleles generated with CRISPR/Cas9. The underlined sequence in wt indicates PAM sequence of sgRNA target. (D) Representative images of male and female wild type and ccdc57 mutants with different genetic background as indicated. (E) The dissected brain and spinal cord in wild type and ccdc57 mutant. Scale bars: 1 cm in panels A, B, D, E. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
| Fish: | |
|---|---|
| Observed In: | |
| Stage: | Adult |
Phenotype Detail
Acknowledgments
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Full text @ PLoS Biol.