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Fig 1
Mutation of ccdc57 leads to scoliosis.
(A) Representative images of male and female wild type and tft168N mutants. (B) Micro-CT images showing lateral and dorsal views of 3-months-old wild type and tft168N mutants. (C) Genomic structure and sequences of wild type, tft168N mutant and two ccdc57 mutant alleles generated with CRISPR/Cas9. The underlined sequence in wt indicates PAM sequence of sgRNA target. (D) Representative images of male and female wild type and ccdc57 mutants with different genetic background as indicated. (E) The dissected brain and spinal cord in wild type and ccdc57 mutant. Scale bars: 1 cm in panels A, B, D, E.
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