FIGURE

Fig. 2

ID

ZDB-FIG-230302-15

Publication

Kamstra et al., 2022 - Leptin regulates glucose homeostasis via the canonical Wnt pathway in the zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Regulation of glucose homeostasis and body weight in adult zebrafish. (A) Glucose tolerance in normal-fed lepa^nz301 fish, lepb^nz302 fish, lepr^nz303 fish, and wild-type controls (n = 12). (B) Baseline blood glucose levels of normal-fed and overfed lepa^nz301 fish, lepb^nz302 fish, lepr^nz303 fish, and wild-type controls. ****p < .0001, two-way ANOVA. (C) Glucose tolerance in overfed lepa^nz301 fish, lepb^nz302 fish, lepr^nz303 fish, and wild-type controls (n = 12). (D) Area under the curve of (A) and (C). *p < .05, one-way ANOVA; ^#p < .05, two-way ANOVA. (E) Body weights of lepa^nz301 fish, lepb^nz302 fish, lepr^nz303 fish, and wild-type control on a 6-week normal diet or overfeeding regime. ***p < .001, repeated-measures ANOVA. (F) Standard length of normal-fed and overfed lepa^nz301 fish, lepb^nz302 fish, lepr^nz303 fish, and wild-type controls at 0, 3, and 6 weeks. *p < .05, one-way ANOVA. (G–J) Examples of leptin receptor-deficient and wild-type zebrafish at the start and end of the overfeeding regime

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB lepa^nz301/nz301 (AB) lepb^nz302/nz302 (AB) lepr^nz303/nz303 (AB)
Condition:	nutrient increased
Observed In:	blood glucose glucose homeostasis whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ FASEB J.