FIGURE

Fig. 5

ID

ZDB-FIG-230217-192

Publication

Guo et al., 2023 - Dynamic network biomarker identifies cdkn1a-mediated bone mineralization in the triggering phase of osteoporosis

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

A molecular network required for osteoclast differentiation is modulated by cdkn1a.

a Differentially expressed genes (|log2Fold change | > 0.3 and FDR < 0.05 were used as thresholds) after cdkn1a knockout (n = 2437 DEGs). b Heatmap of the osteoblast- and osteoclast-associated genes between the cdkn1a^Case9/sgRNA and control groups. c The expression changes of representative DEGs after cdkn1a knockout were validated by qRT‒PCR. d Functional enrichment analysis showing significant KEGG pathways among cdkn1a-regulated genes. e Global view of the cdkn1a-mediated molecular network required for osteoporosis. f GSEA showed that osteoclast differentiation was negatively enriched using cdkn1a-regulated genes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Exp. Mol. Med.