FIGURE

Fig. 2

ID

ZDB-FIG-230212-25

Publication

Hu et al., 2021 - Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis

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Fig. 2

irf7 knockdown zebrafish embryos exhibit severe defects in hair cell (HC) development. (a) Phenotypes of control and irf7‐specific morpholino‐injected Tg(Brn3c:GFP) zebrafish larvae at 72 hpf. (b) Fluorescent imaging of green fluorescent protein (GFP)‐labeled HCs indicates the HC clusters on the lateral line of zebrafish larvae at 72 hpf. (c) Quantification of the number of HC clusters in control and irf7‐specific morpholino‐injected Tg(Brn3c:GFP) zebrafish embryos at 72 hpf. (d) Comparison of the phenotypes of crista HCs (blue dotted circles) in control, irf7‐specific morpholino‐injected and irf7‐specific morpholino & mRNA‐coinjected zebrafish embryos. (e) Quantification of the number of crista HCs in control, irf7‐specific morpholino‐injected and irf7‐specific morpholino & mRNA‐coinjected zebrafish embryos. Error bars indicate standard deviation. ***, P < 0.001

Expression Data

Gene:	GFP
Fish:	s356tTg (AB) s356tTg + MO2-irf7 (AB)
Knockdown Reagent:	MO2-irf7
Anatomical Term:	neuromast hair cell
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s356tTg + MO2-irf7 (AB)
Knockdown Reagent:	MO2-irf7
Observed In:	neuromast neuromast hair cell post-vent region
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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