FIGURE

Fig. 14

ID

ZDB-FIG-230207-42

Publication

Li et al., 2022 - Erianin Controls Collagen-Mediated Retinal Angiogenesis via the RhoA/ROCK1 Signaling Pathway Induced by the alpha2/beta1 Integrin-Collagen Interaction

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Fig. 14

Effects of erianin on the RhoA/ROCK1 pathway in vivo. (A) The mRNA levels of rhoa, rock1I, and mypt1 in adult and embryonic zebrafish retinas exposed to normoxia, hypoxia, or erianin at various concentrations. B (B–I) Protein expression of GTP-RhoA, ROCK1, and p-MYPT1 in adult and embryonic zebrafish retinas under normoxia, hypoxia, or erianin at various concentrations. (B–II) Quantitative analysis of GTP-RhoA, ROCK1, and p-MYPT1 in adult and embryonic zebrafish retinas. The results are presented as percentages of the normoxia group. * Significant difference between samples in the adult zebrafish (paired t-test, P values < 0.05) and in the zebrafish embryos (independent sample t-test, P values < 0.05); ^# Comparison with adult zebrafish induced by low-oxygen without erianin treatment (paired t-test, P values < 0.05) or with zebrafish embryos induced by CoCl₂ without erianin treatment (independent sample t-test, P values < 0.05); † Comparison with normoxic zebrafish embryos without erianin treatment (independent sample t-test, P values < 0.05).

Expression Data

Genes:	ppp1r12a rhoaa rock1
Fish:	WT
Conditions:	chemical treatment by environment: cobalt dichloride chemical treatment by environment: cobalt dichloride hypoxia chemical treatment by environment: chemical entity, hypoxia
Anatomical Term:	retina
Stage Range:	Day 5 to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	chemical treatment by environment: chemical entity, hypoxia
Observed In:	retina
Stage:	Adult

Phenotype Detail

Acknowledgments

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