Gene
rock1
- ID
- ZDB-GENE-100712-2
- Name
- Rho-associated, coiled-coil containing protein kinase 1
- Symbol
- rock1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have GTP-Rho binding activity and Rho-dependent protein serine/threonine kinase activity. Involved in epicardial cell to mesenchymal cell transition; negative regulation of adherens junction organization; and positive regulation of stress fiber assembly. Predicted to localize to cytoplasmic stress granule and cytoskeleton. Is expressed in forebrain and hindbrain. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Chu et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR015008 | ROCK, Rho binding domain |
| Domain | IPR037310 | Rho-associated protein kinase 1, HR1 |
| Family | IPR020684 | Rho-associated protein kinase 1/2 |
| Family | IPR050839 | Rho-associated Serine/Threonine Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | C1-like domain superfamily | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase, ATP binding site | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase domain | Protein kinase-like domain superfamily | Rho-associated protein kinase 1/2 | Rho-associated protein kinase 1, HR1 | Rho-associated Serine/Threonine Kinase | ROCK, Rho binding domain | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PRV2
|
1375 | |||||||||||||
|
UniProtKB:A0A0R4IVY5
|
1359 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available