FIGURE

Fig. 6

ID

ZDB-FIG-230202-46

Publication

Wilms et al., 2021 - Glutaredoxin 2 promotes SP-1-dependent CSPG4 transcription and migration of wound healing NG2 glia and glioma cells: Enzymatic Taoism

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Fig. 6

SP-1 is a main target of glutaredoxin 2′s regulation of migration. A) Treatment with 5 and 10 nM of the SP-1 inhibitor mithramycin A abolished the positive effect of Grx2c incubation on GBM-18 cell migration, ***: p < 0.001 (Student's t-test). B) Survival of GBM-18 cells treated with indicated concentrations of mithramycin A was tested using the Cell Titer Blue assay. C) CSPG4 transcripts in GBM-18 cells treated with 10 or 25 nM mithramycin A measured by qRTPCR and normalized to GAPDH transcripts. D) GLRX2 transcripts in the invading areas compared to all other areas of a tumor according to the IVY GAP project. ***: p < 0.001 (ANOVA). E) The Yin and Yang of the (patho-) physiological consequences of Grx2c regulated CSPG4 transcription. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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