FIGURE
Fig. 6
- ID
- ZDB-FIG-230126-29
- Publication
- Baronio et al., 2021 - Vesicular monoamine transporter 2 (SLC18A2) regulates monoamine turnover and brain development in zebrafish
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Fig. 6
The serotonergic system. A and B, Ventral views of whole-mount 6 dpf larval brains, anterior to the top, processed for serotonin (5-HT) immunostaining. 5-HT immunoreactivity in the brain of a vmat2+/+ larva and clear depletion of 5-HT immunoreactive neurons on its vmat2−/− sibling brain. Scale bar = 75 µm. C and D, Ventral views of whole-mount 6 dpf larval brains, anterior to the top, processed for tph1a RNA in situ hybridisation (ISH). More tph1a-positive neurons are seen in the hypothalamus of a vmat2−/− larva than in vmat2+/+ sibling, particularly on group 3 (dashed box). Scale bar = 75 µm. E and F, Bar chart showing results of high-performance liquid chromatography (HPLC) assay on larvae of the indicated genotype at 6 dpf. Levels of 5-HT and 5HIAA in 6 dpf vmat2+/+ and vmat2−/− larvae. n = 6 for each genotype. Data are mean ± SEM. Student's t test was used for statistical analysis. †P < .01. ‡P < .001
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Expression Data
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| Antibody: | |
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| Anatomical Terms: | |
| Stage: | Day 6 |
Expression Detail
Antibody Labeling
Phenotype Data
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| Observed In: | |
| Stage: | Day 6 |
Phenotype Detail
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Full text @ Acta Physiol. (Oxf).