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Fig. 2

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ZDB-FIG-230126-18

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do Amaral et al., 2022 - The perinuclear region concentrates disordered proteins with predicted phase separation distributed in a 3D network of cytoskeletal filaments and organelles

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Fig. 2

Lysosomes, mitochondria and Golgi are components of the nuclear cloud. Embryonic chick pectoral muscle was processed for transmission electron microscopy and organelles were digitally colored to facilitate the visualization. Images show lysosomes (Ly, in green in A and B), mitochondria (Mt, in red in C and D), endoplasmic reticulum (Er in C), and Golgi (G, in pink in A and B) in proximity with the outer nuclear membrane (Nu). The highly packed nuclear compartment nucleoli (Nuc, in dark yellow) are seen within the nucleus (light yellow) of muscle cells (in A and B). Some lysosomes (in A and B) and mitochondria (in C and D) seem to be adhered to the nuclear surface. Bars in A and C = 1 μm, and bars in B and D = 500 nm. N = 4 independent experiments.

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Reprinted from Biochimica et biophysica acta. Molecular cell research, 1869, do Amaral, M.J., de Andrade Rosa, I., Andrade, S.A., Fang, X., Andrade, L.R., Costa, M.L., Mermelstein, C., The perinuclear region concentrates disordered proteins with predicted phase separation distributed in a 3D network of cytoskeletal filaments and organelles, 119161, Copyright (2022) with permission from Elsevier. Full text @ BBA Molecular Cell Research