FIGURE

Fig. 2

ID

ZDB-FIG-221203-6

Publication

Sander et al., 2021 - Approved drugs ezetimibe and disulfiram enhance mitochondrial Ca²⁺ uptake and suppress cardiac arrhythmogenesis

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Mitochondrial Na⁺/Ca²⁺ exchanger-mediated mitochondrial Ca²⁺ extrusion. Free Ca²⁺ in the supernatant of permeabilized HeLa cells was recorded using Calcium Green-5N before and after injection of 100-μM Ca²⁺ (first arrowhead) followed by a block of mitochondrial Ca²⁺ uniporter using Ru360 (second arrowhead). Addition of 60-mM Na⁺ (third arrowhead) induced mitochondrial Na⁺/Ca²⁺ exchanger-mediated Ca²⁺ extrusion (control, black trace) which could be blocked by the mitochondrial Na⁺/Ca²⁺ exchanger blocker CGP-37157 (control, red trace). Neither ezetimibe, nor disulfiram or honokiol affected NCLX activity (n = 4)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Br. J. Pharmacol.